Mouse Models in the Study of Genetic Neurological Disorders by Brian Popko (auth.), Brian Popko (eds.) PDF

By Brian Popko (auth.), Brian Popko (eds.)

ISBN-10: 0306459655

ISBN-13: 9780306459658

ISBN-10: 146154887X

ISBN-13: 9781461548874

The variety of mouse versions which are on hand for the examine of human genetic neurological problems is big and growing to be speedily. for this reason, it used to be tricky to choose the types that have been reviewed during this quantity. in actual fact, there are very important versions that aren't mentioned, and maybe a quantity two times this dimension might were extra acceptable. additionally, the speed at which new versions are being built and analyzed is quick. As this quantity is going to press, i'm certain that extra mouse genes accountable for evidently happening neurological problems are being came upon and that many new transgenic and mutant mouse traces are being constructed. consequently, this quantity shouldn't be considered as a finished compendium, yet really as an replace of labor in growth. it's exhilarating to witness the short speed at which those versions are being validated as vital instruments within the examine of uncomplicated neuroscience and neurological issues. it is going to be much more fascinating to work out their usage within the improvement and trying out of healing interventions for those ailments. i need to thank all the authors who've contributed to this quantity for his or her time and their services. i might additionally prefer to thank Drs. Timothy Coetzee and Joshua Corbin for his or her suggestion within the collection of the subjects coated. i'm deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the assumption for this quantity, for his information all through its preparation.

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Auerbach, A. , and Joyner, A. , 1994, Multiple developmental defects in Engrai/ed-l mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum, Development 120:2065-2075. , Gold, L. , Koob, G. , Graybiel, A. , 1994, Dopamine D 1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses, Cell 79:729-742. , 1996, Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2, Science 273:645-647. Zhou, Q.

Brennan, M. , Danielson, P. , Kozak, C. , and Sutcliffe, J. , 1989, Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds), Nature 338:70-73. Tsien, J. , Chen, D. , Mercer, E. , Anderson, D. , Kandel, E. , 1996a, Subregion- and cell type-restricted gene knockout in mouse brain, Cell 87:1317-1326. Tsien, J. , Huerta, P. , 1996b, The essential role of hippocampal CAl NMDA receptor-dependent synaptic plasticity in spatial memory, Cell 87: 1327-1338.

For these reasons, considerable effort has been exerted in an effort to develop a means by which to introduce mutations in restricted cell types or at defined developmental stages, or both. One means by which to achieve regional or cell specific gene inactivation exploits the ere/loxP site-specific recombination system of the PI bacteriophage (review in Sauer, 1994). In this approach, the expression of the ere recombinase is targeted to the specific cells of interest in transgenic animals using an appropriate transcriptional control element.

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Mouse Models in the Study of Genetic Neurological Disorders by Brian Popko (auth.), Brian Popko (eds.)

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